Professor of Department of Biomedical Engineering, Tufts University, Medford, Massachusetts, USA

Group Website: www.xulab.us

Qiaobing Xu received his Bachelor of Science degree in Chemistry from Jilin University in July 1999, and his Master of Science degree in Polymer Chemistry from Jilin University in July 2002, and Ph.D. in Chemistry from Harvard University. From September 2007 to August 2010, he conducted postdoctoral research in the Department of Chemical Engineering at the Massachusetts Institute of Technology. Professor Xu joined the Department of Biomedical Engineering at Tufts University in September 2010, where he has remained to date. He also holds joint appointments in the Department of Chemical and Biological Engineering at the Tufts School of Engineering and at Tufts University School of Medicine, and is a member of the Genetics, Molecular & Cellular Biology (GMCB) and Neuroscience (Neuro) programs at the Tufts Graduate School of Biomedical Sciences. He has received numerous honors, including the Pew Scholar Award in Biomedical Sciences (2013), the NSF CAREER Award (2015), election as a Fellow of the American Institute for Medical and Biological Engineering (AIMBE, 2020), and designation as a Senior Member of the National Academy of Inventors (NAI, 2024). He also serves as Co-Editor-in-Chief of WIREs Nanomedicine and Nanobiotechnology, published by Wiley.

Representative Publications

[1] Qiu, M.; Glass, Z.; Chen, J.; Haas, M.; Jin, X.; Zhao, X.; Rui, X.; Ye, Z.; Li, Y.; Zhang, F.; Xu, Q.  Lipid nanoparticle-mediated co-delivery of Cas9 mRNA and single guide RNA achieves liver-specific in vivo genome editing of Angptl3. PNAS 118, e2020401118 (2021)

[2] Qiu, M.; Tang, Y.; Chen, J.; Muriph, R.; Ye, Z.; Huang, C.; Evans, J.; Henske, E. P.; Xu, Q. Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis. PNAS  119, e2116271119 (2022).

[3] Chen, J.; Ye, Z.; Huang, C.; Qiu, M.; Song, D.; Li, Y.; Xu, Q. Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response. PNAS 119, e2207841119 (2022)

[4] Gao, S.; Guan, H.; Bloomer, H.; Wich, D.; Song, D.; Khirallah, J.; Ye, Z.; Zhao, Y.; Chen, M.; Xu, C.; Liu, L.; Xu, Q. Harnessing non-Watson-Crick’s base pairing to enhance CRISPR effectors cleavage activities and enable gene editing in mammalian cells. PNAS  121, e2308415120 (2024)

Zhao, Y.; Song, D.; Wang, Z.; Huang, Q.; Huang, F.; Ye, Z.; Wich, D.; Chen, M.; Khirallah, J.; Gao, S.; Liu, Y.; Xu, Q. Antitumour vaccination via the targeted proteolysis of antigens isolated from tumour lysates. Nature Biomed. Eng. 9, 234–248 (2025)